I am an alternative physician and I have spend 20 years researching the effects of cadmium on health and the environment. See www.pinkhammedical.com. Cadmium is associated with breast, prostate, lung, and pancreatic cancer. It is a carcinogen, co-carcinogen, and anti-carcinogen and its effects are unpredictable. It gets into rapidly growing cells with fluid membranes. Successful use of chemo and radiation may involve cadmium effects on the cancer cells. Likewise toxic effects of these therapies may involve cadmium effects on normal cells. Certainly the resurgence of chemo and radiation resistant cancer cells involve cadmium resistance.
Except for cigarette smoke, human exposure to cadmium was not felt to come from air pollution. Unfortunately there are many sources of cadmium air pollution coming from trash burning power plants, fossil fuel combustion, and super phosphate fertilizers getting into the air from plants. However, both passive and active smoke greatly increases cadmium exposure. Cotinine correlates with cadmium. Higher Cotinine and NNAL levels in the urine of smokers increases their risk of lung cancer in the next 5 years 8.5 times. Cadmium is highly synergistic with chemicals and by affecting the liver can double the levels of the chemical in the system with co-exposure. Heart disease and strokes kill more smokers than lung cancer. These are also cadmium toxic effects.
Since 1980, with the elimination of leaded gasoline, the cadmium in the air has become more bio-available, making non-smokers more exposed to cadmium. Estrogen increases cadmium uptake so women and middle aged men who are under stress and making more estrogen from their adrenals are more exposed to cadmium.
In general: a nutrient dense, high fiber, plant food based diet, with good fish oils, a good night sleep, cardiac coherence exercise (rhythmic slow movements), a GI tract with good probiotics and no yeast or toxic bacteria from taking antibiotics, and happiness ( love, end of stress, Low Dose Naltrexone , meditation, spirituality) counter the toxic effects of cadmium. Although cadmium is not mentioned, the AntiCancer Action Plan in Anti Cancer a New Way of Life by David Servan-Schreiber is an excellent general health action plan that I think would contribute more to Health Care Reform than any legislation Congress could pass. It is an excellent anti-cadmium approach. I have only 5 minor disagreements with his suggestions.
Cadmium’s effect on health has been generally overlooked due to erroneous assumptions of toxicologists and lack of knowledge of other health professionals. There is a great deal known about its effects however in bacteria, fungi, and cells of all kinds. This is particularly interesting since so much of the research on cancer is on signal transduction modification. Cadmium increases IL-6, IL-8, works through the MAPK pathway via p38, it plays a role in nuclear transcription via AP-1. I t activates NFK-beta. It generates ROS (reactive oxygen species) which play a role in angiogeneisis. It down regulates mitochondria which may increase glycolysis.
ESTROGEN
If you look up estrogen and lung cancer you will find that 61 % of lung cancer cells, especially adenocarcinoma have a nuclear estrogen receptor beta, 70.3 % of males where it is associated with a more favorable prognosis. The anti-estrogen fasolodex (no other anti-estrogen) kills cancer cells especially in conjunction with a blocker of EGFR. There is one NCI trial currently using faslodex and tarceva. ER beta is found in osteoclasts in the bone and in the brain. This is one rationale for using faslodex for bone and brain metastasis. Probably also useful for adrenal metastasis since estrogen can be produced in the adrenal gland.
Binding of estradiol to ER initiates dissociation of HS protein followed by dimerization and nuclear localization, binds to DNA, AF-1 transcription via MAPK pathway mediates angiogenisis. Estrogen can activate EGFR ( HER-2). Block with Fulvestrant (faslodex 250 mg IM every 3 weeks)
There is now an experimental radiaoactive estradiol that can be used in PET scan that can determine estrogen receptor positivity in primary and metastatic tumors. It was designed for determining hormone resistance in breast cancer but might prove helpful in determining estrogen positivity in any tumor.
In my studies of urinary hormone metabolites done by Genova I have found and the laboratory confirms that there is a very high predominance in men and women of excess 4-OH estradiol, the carcinogenic estrogen , and also a decrease in its methylation and a general decrease in methylation. Hypomethylation is another effect seen in cadmium studies.
GENISTEIN
In soy products. It is an estrogen receptor beta agonist. It inhibits Il-6 which makes cisplatin more effective. Other substances are IL-6 inhibitors It inhibits GLUT-1 expression which may be important for Taxol getting into the cell and so don’t use soy with taxol.
Alternative anti estrogen therapies include 12 mg of iodine, 200 mcg of plant based selenium, tocotrienol.
BLOCK Il-6
Il-6 is increased by stress ( Cd effect) , lack of sleep, and depression. It increases bone resorption via MAPK Cd pathway). Increased in hormone refractory prostate cancer. It increases platelets in circulation. If not bone marrow suppressed one can check Il-6 activation with platelet count, perhaps. Statins and N-bisphophonates like zometa inhibit IL-6. Alternatives: fish oils, polyphenols in green tea, colorful berries, grape seed extracts, spices like turmeric and black pepper ( curumin and bioperine) Chinese herb magnolia officinales inhibits IL-6 and Low dose naltrexone (LDN) especially in combination with alpha lipoic acid which chelates and detoxifies cadmium.
BLOCK Il-8 ( increased by Cd)
IL-8 is an angiogenesis factor that promotes growth of NSCLC negatively correlated with survival. Increases resistance to apoptosis from radiation and cisplatin.
BLOCK c-Met (HGF/C-met over-expression associated with poor prognosis mediated by cox-2 PG-E2 (cadmium pathway) inhibit with celebrex . COX-inhibition enhances Tarceva effects.
alternatives: Live Right For Your Type by Peter D'adamo page 234 melatonin, curcumin plus all strategies that block Cd
BLOCK NFKBeta
By blocking Cd, Green tea (ECGC) many other herbs and spices including oleander
BLOCK EGFR ( Tarceva, Iressa, Erbitux)
alternatives: See Live Right for your Type (LRFYT) by Peter D’Adamo Page 232 to 234
*Melatonin up to 20 mg a night
*Curcumin (can use 1 T turmeric and 1 t ginger twice a day with olive oil, garlic, and black pepper in food or use capsules of curcumin and bioperine)
* Quercitin ( best absorbed with bromelain) can take up to 6 capsules a day ( found in the brown skins of yellow onions) can put in crock pot soups and let it leach into the liquid.
* Rosemary also can be used in cooking
* Avoid wheat and wheat germ ( major disagreement with Anti Cancer book see LRFYT)
EGFR, NFKbeta and IL-6 are a cancer pathway and inflammation pathway.
BLOCK HIF-1
Regulates angiogenesis. Drugs Avastin, Sutent, and others block angiogenesis
related to glycolysis and low external pH around cancer cells
Deep slow breathing, cardiac coherence, use of oxygen or hyperbaric oxygen
BLOCK GLYCOLYSIS
Dichloroacetate (DCA) see WEB page. Take intermittently to avoid neuropathy 5 mg /Kg twice a day 5 days on and one day off. Watch for high BP. Monitor with LDH ( p34 hypoxia induced stress protein is an isozyme of LDH which cadmium, the mediator of the stress response, can increase ). Alpha Lipoic Sustain by Jarrow 300 mg twice a day is a good blocker of cadmium toxic effects that DCA could cause.
BLOCK HISTONE DEACETYLASES (HDAC’s)
FK-228, depsipeptide Suppresses the RAS MAPK pathway ( Cd pathway) also folate antagonist/ Alimta is folate antagonist alternatives: Valproic acid ( generic Depakoate a common anti-epilepsy drug RX is required) also blocks MAPK and anti-folate plus Parthenolide (PKC inhibitor) from fever few ( can get the pure compound on line) Vit E and tocotrienol can also block PKC. Valproic plus Parthenolide plus Faslodex for resistant breast cancer cells
blocking MAPK helps with K-ras positive resistant tumors.
BLOCK IGF-1 (insulin derived growth factor)
Reason to keep blood sugar stable. Swings in blood sugar increase insulin levels ( can tell by belly fat accumulation) Increased IGF-1 activates K-ras confers resistance to EGFR antibodies. IGF-1 favors progression of small lesions. Activation of K-ras associated with adverse prognosis. Synergistic effect of inhibition of IGF receptor, EGFR and HER-2 (INSM-18 dual inhibitor of IGF-1 and HER-2) Panitumamab ( human EGFR Ab) and stable disease.
BLOCK mTORC
Curcumin and Bioperine
Methionine restriction ( low protein no egg yolks) important for bone lesions
BLOCK HS-90 ( heat shock protein 90 )
IP1-504 Seattle Cancer Alliance better response with wild type EGFR
Jill Goddart 617-453-1014 Clinical Trial. See above possible role with
estradiol.
BLOCK BONE TURNOVER
Inhibit PG-E2 with anti cadmium strategies. Anti-Cox like Celebrex or herbal alternatives. Inhibit IL-6. Vitamin D-3 up to 20,000 units a day (monitor calcium to be sure levels don’t go above 11. Vit K2100 to 1000 mcg a day ( high levels in NATTO fermented soy beans) 7-keto DHEA adrenal hormone that does not convert to other hormones. Helps convert fat into muscle: anabolic
REDUCE NEURO AND NEPHROTOXICITY
Dimensa, free thiols try Alpha Lipoic acid Sustain 300 mg (Jarrow) 1 tab twice a day 48 to
72 hour after chemo and 2 days before chemo. Another protocol stop herbs 48 hours before chemo and resume 72 hours after chemo.
IDEAL THERAPY based on cell killing. Expose cancer cells to cadmium to determine resistance. If no killing in 20micromolar Cd, highly resistant.
GENE typing also very helpful.\
ALTERNATIVE THERAPIES
* LOVE. We are born to love. Activates dopamine the reward chemical.
Lowers the perception of pain. Makes life worth living.
* SEE DCA WEB page for a complete protocol used by a woman who did not use DCA
* DCA anti-glycolysis. Available without RX from UK on line
* Beta glucan increases chemotherapy efficacy
*Oleander potentiates chemo and radiation ( Tony Isaac Oleander Protocol)
* Tian Xian Chinese herbal medication approximately $400 a month
* Exercise ( cardiac coherence movements) alleviates fatigue
* Inhibitors and inducers of CYP3A4 should be avoided with certain
chemos: grapefruit, pomegranate, and gingko
* Use of B-1, B-6 and B-12 to prevent neurotoxicity
* Noscarpine ( affects microtubles target of taxotere) anti cough and
anti-cancer. Increases heart rate, alertness, decreases sleepiness.
Cannot take with Coumadin. Can obtain on line.
*Marinol (RX) or medical marijuana anti nausea, appetite stimulant,
and anti-cancer
* Low dose Naltrexone (LDN) 1 to 4.5 mg with garlic, B-6 10 to 50 mg
at bedtime see WEB pages lowers Il-6. terminates the stress response,
pain reliever by enhancing endogenous opiates. Can’t be used with
opiates ( exogenous opiates). Requires a RX. Very inexpensive. Best in combination with alpha lipoic acid.
* Organic germanium. Cadmium chelator. Excretes
cadmium through the urine. See Web page. 150 mg 3 times a day.
Reportedly good for pain. Terminates the stress response.
* TMZ more positive effects with green tea (ECGC)
* Nutritional lithium OTC lithium orotate for low WBC, anxiety,
depression, alkalinizing
* Memastine for cognitive dysfunction from Whole brain radiation
IMPROVING IMMUNE FUNCTION
See Immune Restoration Handbook by Mark Konlee
See Anti Cancer a New Way of Life
IMPROVING ENERGY (Mitochondrial function)
* D- Ribose ( Corvalen) 2.5 to 5 gm 2-3 times a day. May take 2-3
weeks to see benefit
* Co enzyme Q 10 100 mg a few times a day
*Acetyl L carnitine 250 to 500 mg twice a day ( especially good if
unintended weight gain, helps turn fat into energy)
* Rhodiola rosea herb that improves energy anti cancer, and decreases
toxicity of chemo
* Vinpocetin 5 mg 1-2 times a day increases ATP in neurons, increases
short term memory, focus, concentration. In high doses decreases
platelet clumping, may decrease risk of stroke or clots. Used to
improve brain function following strokes
* Magnesium as magnesium ascorbate (vit C), very good for
constipation, magnesium inositol(Cenitol) very good for overall neuronal function
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